Multiple Systemic Infectious Diseases Syndrome
Could You Have Lyme Disease? Take This Questionnaire.
MSIDS - Multiple Systemic Infectious Diseases Syndrome
MSIDS is a symptom complex of Lyme disease and multiple associated tick borne coinfections that encompasses not only infections with Borrelia burgdorferi, the tiological agent of Lyme Disease, but also other bacterial infections, viral infections, parasitic infections, and fungal infections.”
Why Can’t I Get Better? by Richard I. Horowitz, M.D
MSIDS Symptoms Can Include:
| Abnormal liver functions Allergies Autonomic nervous system dysfunction Endocrine abnormalities Environmental toxicity Enzyme deficiencies Functional medicine abnormalities in biochemical pathways | Gastrointestinal abnormalities Immune dysfunction Inflammation Mitochondrial dysfunction Neuropsychological issues Nutritional deficiencies POTS Pain issues | Physical de-conditioning Sleep disorders Day sweats, night sweats, chills Shortness of breath with unexplained cough- possibly from babesiosis, a malaria-type parasite contracted through tick bites. |
“The ILADS guidelines stress the importance of a doctor’s clinical judgment in making the diagnosis, because the scientific literature has found that the existing testing is unreliable. The IDSA narrowly restricts the diagnosis to include the CDC criteria. However, many doctors in the United States do not follow IDSA guidelines. Instead, my model allows Lyme to be redefined as MSIDS: a clinical syndrome that encompasses multiple overlapping factors that keep patients chronically ill.”
- Richard Horowitz, MD
Multiple Systemic Infectious Diseases Syndrome
Six Signs to Watch For:
1. You have more than one symptom
- Fatigue
- Joint and muscle pain
- Tingling
- Numbness and burning sensations
- A stiff neck
- Headaches
- Light and sound sensitivity
- Dizziness
- Difficulty falling asleep and staying asleep
- Memory and concentration problems
- Chest pain with palpitations
- Psychiatric symptoms such as depression and anxiety
2. You have good days and bad days.
A hallmark of Lyme disease is that the symptoms tend to come and go with good and bad days.
3. The pain changes and moves around the body
Another classic trait of Lyme disease is the migratory nature of the pain. The muscle and joint pain, as well as the tingling, numbness and burning sensations often tend to come and go and move around the body. For example, one day the joint pain might be in the knees. Three days later, it's in the shoulders, and two days later it's in the ankles.The same symptoms can happen with Lyme neuropathy, where the bacteria have affected the nerves, and the tingling, numbness and burning sensations migrate to different areas around the body.
4. If you're a woman, your symptoms worsen right around your cycle.
Women will often have a worsening of Lyme symptoms right before, during, or after their menstrual cycle. Lyme disease symptoms are known to change with fluctuating levels of estrogen and progesterone.
5. Your symptoms improve when you're taking medication for other ailments.
Patients taking antibiotics for an unrelated problem (such as upper respiratory infection or urinary tract infection), will often report that their symptoms are much better while taking the antibiotic, and worsen when the antibiotic is stopped. Conversely, some individuals feel much worse on antibiotics, where all of their symptoms are intensified. This is called a Jarish-Herxheimer reaction, where the Lyme bacteria are being killed off, and temporarily worsen the underlying symptoms.
6. Blood tests have confirmed this.
The sixth and final point to determine if your symptoms are due to Lyme disease is to ask your health care provider to run a blood test called a Western Blot through a reliable laboratory, like IgeneX labs in California. There are over 100 different strains of Lyme disease in the US, and 300 strains worldwide, and IgeneX uses several strains to improve their testing.
Although there are several different laboratory tests to diagnose Lyme disease (like an ELISA test, Western Blot, PCR (DNA) test or occasionally a culture), these tests each have their pros and cons, and can miss establishing the diagnosis because they are not sensitive enough to always pick up the presence of the bacteria. There are, however, five bands (proteins) on the Western Blot that are specific for exposure to Lyme. These proteins (bands) are the 23, 31, 34, 39 and 83/93 kdA bands. Any one of these bands on a Western blot with the above symptoms mentioned (having been properly ruled out for other diseases) is pathognomonic for Lyme disease. A bullseye rash is also a classic manifestation of Lyme disease, and does not require a positive blood test, but less than 50% of people may get the rash, and it may be located in a part of the body where the rash cannot easily be seen.